afh gut microbiome restoration detoxification 62bc4990e63f1

AFH Gut Microbiome Restoration : Detoxification

AFH Gut Microbiome Restoration : Detoxification

 

Welcome to AFH restoring the gut microbiome programs:  Detoxification. The human microbiome is composed of all the microorganisms colonizing the body.  The gut microbiome can be considered an organ in its own right. It weighs 1.5 kg, it has high metabolic or processing capability that rivals that of the liver, and it plays a vital role in immune and GI maturation. It also plays a role in normal central nervous system development, allows for a reservoir or back up function of essential microflora in case of infection or damage, regulates the immune system and influences our metabolic GI function.  Our genetic material is also less than 1% of the total genetic material of the microbiome.  

There are five main areas of discussion regarding the microbiome, to help you remember we’ll call them the five D’s:  dysbiosis, defense, diversity, disease and detoxification. Today we’ll be discussing the gut microbiome in terms of detoxification.

The gut microbiome is intricately involved with the immune system. In addition to its functions of defense, recognizing pathogen associated molecular patterns or PAMPs, the immune system is also involved in the removal of waste or molecules with damage associated molecular patterns or DAMPs.  We now know that some of the variability in the response to drugs and drug doses in different people can be accounted for by differences in the composition of each individual’s microbiome. Also, persistent organic pollutants or POPs may also be neutralized or removed with the help of the gut microbiome. These pollutants are often trapped in fat or adipose tissue and can account for why people can’t lose excess weight.   The gut microbiome also changes or modulates gut derived signals to the brain especially in obese individuals which can cause neuro inflammation or alter behaviors.

Supplementation with prebiotics, probiotics, or symbiotics is a good strategy to use in addition to nutrition and lifestyle modifications, to decrease depression, alter eating behaviors, and lower body burden of pollutants and is a more natural way to treat our national obesity epidemic.

A 2014 randomized open label pilot study published in the journal mBio demonstrated that a probiotic yogurt product infused with Lactobacillus rhamnosus GR-1 (LGR1), had a positive health-supporting effect in pregnant women exposed to mercury. A 2018 study published in Gut Microbes also used LGR1 with similar results. The researchers concluded that LGR-1 “…may offer a simple and effective means to reduce the amount of heavy metals absorbed from foods in contaminated regions of the world.”*

In a recent review, it was suggested that GI microbes might affect obesity and diabetes by altering the absorption, disposition, metabolism and excretion of environmental chemicals. There are four different types of interactions: first, the GI microbiota can metabolize a variety of environmental chemicals, directly upon ingestion or after their conjugation by the liver. Reciprocally, environmental chemicals can interfere with the composition and/or metabolic activity of the GI microbiota, with potentially bad consequences for the host.

A well-functioning detoxification system is clearly important for maintaining our health in the modern environment. Pollutants, hormones, heavy metals, food toxins, pathogens, and cellular waste all require specific processes to remove them from the body. 

 

When it comes to detoxification of ingested medications, environmental toxins, cellular waste we think of the liver but that is not the only organ of detoxification The gut and the gut microbiome is another primary organ of detoxification.

We’ve discussed the phases of detoxification elsewhere but the basic principle is as follows: You may recall learning that there are three primary phases of detoxification:

Phase I: cytochrome P450 and other enzymes prepare the toxic molecule to be transformed by introducing polar groups via oxidation, reduction, or hydrolysis

Phase II: binding or conjugation of neutralizing agents via processes like methylation, acetylation, or sulfuration

Phase III: physical removal or excretion

It should be noted that the wrong microbes may increase the effect of toxins on the human body by making enzymes to break neutralizing chemical bonds and allow recirculation of the toxins by reabsorption by the gut. Irritating microbes can also cause intestinal permeability or damage to the gut lining allowing for toxins, incompletely digested foods or pathogenic bacteria to cross into the blood stream. The wrong microbes can also increase phase 1 of detoxification which often leads to a more toxic intermediate molecule which then needs to be neutralized by phase 2 detoxification. Having too rapid or excessive phase 1 without increasing or balanced with an appropriate neutralizing capacity of phase 2 can lead to more toxicity. This was shown in an experiment with germ free mice which had higher phase 2 than phase 1 but this was reversed with certain microbes

Supplements such as PomBio X Dietary promote short chain fatty acids which in turn increase colonocyte expression of phase II enzyme glutathione S transferase (GST).  Other dietary components like the polyphenols found in ProBio Rainbow also influence the gut microbes may play a role in the liver and gut levels of phase II enzymes which is important to neutralize the toxins for excretion.

Drugs also need to be metabolized and detoxified. Nearly a century ago, research groups discovered that gut microbes play a role in drug metabolism. Today, more than 50 drugs have been shown to be metabolized by gut bacteria.

Three steps to optimize your body’s detoxification capability through the gut microbiome include

  1. Remove or Reduce exposure to chemical pollutants, drugs like antibiotics, and heavy metals  as much as possible
  2. Optimize detoxification pathways with nutrients and supplements
  3. Support a healthy gut microbiome

Step one can be supported with prebiotic fibers and binding agents like FiberLean or Fiber 365. Step two can be achieved with the 14 day Detox kit, Biotransform, or Daily Reset. Finally, step three can be achieved with Probio 350, Probio Plus, ProBio 100, ProBio 30 SB, PomBioX, and ProBio Phyto (Rainbow).

ProBio 350 is a high potency multi strain probiotic that’s pharmaceutical grade with 350 billion colony units of 18 bacterial strains.  ProBio Plus has 225 billion colony units of 6 strains of the most beneficial bacteria with a prebiotic. ProBio 100 has 100 billion colony forming units of 4 strains of bacteria including lactobacillous plantarum for gut lining integrity and immunity.  ProBio 30 SB has 30 billion colony forming units of 6 strains of bacteria including saccharomyces boulardii.  PomBioX has a concentrated pomegranate and citrus extracts that promote short chain fatty acids and the bacteria that support phase two detoxification. ProBio Phyto (Rainbow) has polyphenols that also support short chain fatty acids and detoxification along with non-dairy based probiotics.

For a more extensive overview of restoring the gut microbiome please see the written or video blog AFH restoring the gut microbiome program: diversity. To get an evaluation of your microbiome, start the AFH gut microbiome restoration program, or benefit from other AFH health programs, please email iinfo@jeffreymarkmd.com, visit www.allfunctionalhealth.com, or call (925) 736-9828.

 

So take care and stay healthy.

 

Jeffrey Mark, M.D.

 

Our office location in San Ramon is a short drive to the Silicon Valley including Palo Alto, Menlo Park, Atherton, Portola Valley, Los Altos, Los Altos Hills, San Jose, Cupertino, Mountain View, Burlingame, Hillsborough, San Mateo, San Francisco, Piedmont, Berkeley, Walnut Creek, Danville, Alamo, Diablo, Pleasanton, and surrounding areas. Telemedicine/Telehealth services are now available in the comfort of your home so no need to drive across the bay anymore to access your Quadruple Board Certified physician.   We are able to service all 50 states and send test kits and nutraceuticals directly to your home. Call us to find out more about our many services.  925-736-9828

 

 

Our office location in San Ramon is a short drive to the Silicon Valley including Palo Alto, Menlo Park, Atherton, Portola Valley, Los Altos, Los Altos Hills, San Jose, Cupertino, Mountain View, Burlingame, Hillsborough, San Mateo, San Francisco, Piedmont, Berkeley, Walnut Creek, Danville, Alamo, Diablo, Pleasanton, and surrounding areas. Telemedicine/Telehealth services are now available in the comfort of your home so no need to drive across the bay anymore to access your Quadruple Board Certified physician.   We are able to service all 50 states and send test kits and nutraceuticals directly to your home. Call us to find out more about our many services.  925-736-9828

 

 

 

Author
Jeffrey Mark, M.D.


Helping clients with compassionate and comprehensive medical care for over 25 years with 4 board certifications in functional medicine, gastroenterology, internal medicine, and anti-aging/ regenerative medicine . IFMCP, ABIM Gastroenterology, NPAS Internal Medicine, ABAARM.

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Accessibility Toolbar