afh restoring the gut microbiome disease 62bc499df0413

AFH Restoring the Gut Microbiome : Disease


Welcome to AFH restoring the gut microbiome programs:  disease,. The human microbiome is composed of all the microorganisms colonizing the body. The human microbiome is composed of all the microorganisms colonizing the body.  The gut microbiome can be considered an organ in its own right. It weighs 1.5 kg, it has high metabolic or processing capability that rivals that of the liver, and it plays a vital role in immune and GI maturation. It also plays a role in normal central nervous system development, allows for a reservoir or back up function of essential microflora in case of infection or damage, regulates the immune system and influences our metabolic GI function.  Our genetic material is also less than 1% of the total genetic material of the microbiome.  


There are five main areas of discussion regarding the microbiome, to help you remember we’ll call them the five D’s:  dysbiosis, defense, diversity, disease and detoxification. Today we’ll be discussing  the gut microbiome in terms of disease and give you an example of what types of imbalances occur in certain types of disease. 


The evaluation of the microbiome can consist of examining stool and certain stool tests can reveal the bacteria, both the number and types of bacteria. Dysbiosis, as we’ve mentioned before, is an imbalance of the bacteria . Certain bacteria have been found to be more common in certain disease processes. This chart is an example of what bacteria  we find in certain diseases and imbalances of the bacteria that are present. This is not meant to be as a diagnostic tool exclusively, but to be used in conjunction with the clinical picture that people present with. So we’re looking at the types of stool, you can see certain types of bacteroides species are found in higher amounts in these disease processes, which include Irritable bowel syndrome, inflammatory bowel disease, metabolic syndrome, chronic fatigue, autoimmune,  type two diabetes,  or high blood pressure and mood disorders. For example, bacteroides  species  are higher in  irritable bowel syndrome,  but not necessarily in inflammatory bowel disease, and not necessarily in type two diabetes. But otherwise, there are other similar patterns occurring within the general bacteroides species. For the Firmicutes we can see a certain type of pattern as well, with certain disease processes, as we’ve mentioned above. For example, this particular bacteria, Faecalibacterium prausnitzii ,   is found in higher amounts in irritable bowel syndrome, autoimmune disease and mood disorders for polio bacteria phylum, you can see that in this particular example. If you have a high amount of Oxalobacter formigenes , you can have a higher association with the IBS,  metabolic syndrome, chronic fatigue, and mood disorders. Other things that you can see in the stool is pancreatic  elastase, which is one of the breakdown products for enzymes for digestion. And you can see that they’re decreased across the board. Other things we look at is total fecal fat, which represents more fat in the stool or a possible malabsorption problem. This can occur given symptoms that are associated with irritable bowel syndrome. Metabolic Syndrome chronic fatigue, autoimmune. High blood pressure and mood disorders. Again, these are not diagnostic but these are things to consider as part of the evaluation process. Fecal calprotectin is very important because this is an inflammatory marker, and is found in association with inflammatory bowel disease, but can also be elevated in high blood pressure, and also in people that take non steroidal anti inflammatories or aspirin. Incidentally, fecal calprotectin has been elevated in COVID-19 patients as well. Short chain fatty acids are important because they are the preferred fuel for the colonocytes in the colon or colon cells, and they’ve been found to be decreased in people with chronic fatigue, and with autoimmune disease as well.  We’ve mentioned before that increasing short chain fatty acids with certain probiotics such as PomBio x which contains pomegranate extract and citrus extract promotes bacteria to produce butyrate and other short chain fatty acids, which actually attract and promote lactobacillus as well, which helped to balance yeast and also to help decrease inflammation and is helpful obviously for autoimmune processes. Beta glucuronidation is important, possibly in autoimmune and mood disorders, and this enzyme breaks the bonds of. a toxin bound to a carrying or neutralizing molecule. Breakage of this bond  allows for the re-circulation of certain toxins that the body’s trying to get rid of or waste products that the body’s trying to get rid of as well. 


So here is a general summary on  treating  irritable bowel syndrome and inflammatory bowel disease via restoring or rebalancing the microbiome. For the irritable bowel syndrome we use probiotics to help restore the dysbiosis. Based on the stools, we will restore the bacteria that are missing or decrease the bacteria that are in excess. But in general, we will use a high potency multi species, pharmaceutical grade, probiotics, such as ProBio 350 or ProBio plus, and with the profile plus there is a prebiotic present as well, to promote the desired species of bacteria. If there’s a good response we continue with the high dose probiotic, or we can try to wean to lower those probiotics with ProBIo 100 or ProBIo. SB 30  for maintenance.


As part of the treatment protocol we would treat any detected food allergies and food sensitivities, we would also make sure to evaluate for gluten sensitivity as well. There may be a role  for digestive enzymes which is DigestaMax. In the case of inflammatory bowel disease and Crowns,, it’s important to use saccharomyces boulardii  in a rotating schedule so we are using Pro Bio 30 SB, along with the high potency Probio 350 or ProBio Plus . It’s best to select a high potency multi strain probiotic that’s pharmaceutical grade like ProBio 350  with 350 billion colony units of 18 bacterial strains or ProBio Plus, with 225 billion colony units of 6 strains of the most beneficial bacteria with a prebiotic, and ProBio 30 SB with 30 billion colony forming units of 6 strains of bacteria including saccharomyces boulardii.  For a more extensive overview of restoring the gut  microbiome please see the  written or video blog  AFH restoring the gut microbiome program:diversity. To get an evaluation of your microbiome, start the AFH gut microbiome restoration program , or benefit from other AFH health programs, please email, visit www, or call d(925) 736-9828. So take care and stay healthy.


Jeffrey Mark, M.D.

This transcript was computer generated.

Jeffrey Mark, M.D.

Helping clients with compassionate and comprehensive medical care for over 25 years with 4 board certifications in functional medicine, gastroenterology, internal medicine, and anti-aging/ regenerative medicine . IFMCP, ABIM Gastroenterology, NPAS Internal Medicine, ABAARM.

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