what you should know about the boosters 62bc4953a5acf

What you should know about the Boosters

Hello, it’s Dr. Jeffrey mark. Today I’d like to talk to you about boosters. I’ve had a lot of questions from many people asking me about the vaccine boosters. And most recently, the FDA and CDC have come up with some guidelines on October 20 regarding the use of COVID-19 vaccine boosters, so as a quick review, we know that the first vaccine that came out was for Pfizer and that’s Pfizer BioN tech and what happens with this vaccine is you get a first shot and then three weeks later you get a second shot. And the next vaccine that became available was Moderna. And you got a first shot and then four weeks later, you have a second shot. The final vaccine that came out that’s authorized was the J & J and for that one first and only shot. Now the CDC has authorized booster injections for Pfizer after the second injection. If it’s been six months and you’ve met the following criteriaL  if you’re over 65 or if you’re in a high risk group such as immunocompromised or any other risks or frequent exposure like health care workers you can get injections if you’re 18 to 64 years of age. You can get a booster and I’ll tell you what your choices are there. If you’re Moderna it’s kind of similar. Six months after your second injection, if you’re greater than age 65 or if you’re in the high risk or frequently exposed group you can also qualify for a booster. The J &J  is a little bit different. If you have had the first injection and only injection, two months later, you can get another injection, which is the booster,  if you’re over 18 and I’ll show you in a few minutes why that’s likely the case why they’re encouraging everyone with the j&j to get a booster injection. So what are your choices in terms of boosters? Well, the CDC is authorized for if you had a Pfizer you can get a second Pfizer, you can get the half dose Maderna which is authorized now is a booster or he can get the j&j. So this applies to Moderna as well. For their booster. You can have the same choices. Pfizer another dose of the Maderna but at half dose, because that’s what was authorized. Or you can get to j&j. And for the j&j same choices Pfizer half dose Maderna. So now that you know what the CDC recommendations are, and boosters, you might want to ask, well, Are there studies which booster is better for what combination? And there’s a preliminary study that you can see on your screen here called “A heterologous SARS Cove to booster vaccinations, a preliminary report.”  And this report actually was generated from a number of hospitals and other facilities, university settings and Kaiser data and they pulled them all together and what this study looked at, let me show you. So this is basically they looked at 458 people, and approximately 154 got Maderna 150 j&j and about 154 had Pfizer. They were fully vaccinated. They looked at giving them a booster after 12 weeks, and then roughly split people up in approximately groups of 50 in each area, and those that received the Moderna so approximately 50 got another Moderna. And Pfizer, 50 got j&j as their secondary booster. And another 50 got Pfizer and then for the j&j. They did the same thing so about 50 Moderna  50 got j&j and another got Pfizer after the 12 weeks and for Pfizer the same thing, so split  50 Moderrna 50, j&j and 50 Pfizer. So we’ll look at the data of what was found. So this is the overall data. Now looks like a lot to look at. And we’ll go through some of these briefly but there’s a summary slide that actually will pull it all together. So as I mentioned, these are the groups. It’s basically looking at nine different groups of people, the initial people that had the J and J. You can see there’s 51 and they had 57.1, which is antibodies in this one just looked at antibody assay. So this is on day one, obviously. This is before any effects of the booster. So this is what their baseline is at. And for Moderna and Pfizer by Intel, you can see that in most of these groups, their baseline antibody rates are much higher, which does seem to correlate with the fact that Maderna and Pfizer have lower rates of symptomatic infections. Also protective, obviously, against hospitalizations, Perhaps the lower antibody titers that you can see 57.1. 71.3 and 75.1. The starting lower titers of the Jansen/ J&J  may explain why there may be more symptoms less protection regarding actual infection, symptomatic infection, but still there was the protection from hospitalizations, but you can see the much higher starting titers, for Moderna, Pfizer BioNtech route on this first line. So, on day 15 After getting the booster you can see focusing on  j&j first. You can see if you got JJ and you had the Moderna as a booster and day 15 You went up with your antibodies and went up to this number, as units per milliliter. This Moderna booster should be noted  was 100 micrograms. And the current booster that’s authorized, as I mentioned before, is a half dose of Moderna which is 50 micrograms. So the data is not exactly applicable. But you can see that there’s quite a bit of a response if you’re had j&j and was boosted with Moderna/ On day 29. It’s still a very robust response and you can see here that if you had Maderna as a baseline, first two injections fully vaccinated, then getting Moderna as a booster. So you started here. So if you had the Moderna and then you had so you can see you’re starting off at a higher baseline 859 units per milliliters of binding antibodies, you had a very rigorous response by day 15. And again, this is with the full dose of 100 micrograms as the booster when currently it’s just approved for the 50 microgram dose. So it’s unknown as to how much the half dose will increase, but obviously, there should be an increase as well that hasn’t been studied. And then by day 29, of course, things do settle down a little bit. But you still have a very robust response. Likely if you had, in a similar manner, if you had Pfizer, bIONtech as your full vaccination dose. 12 weeks later, you received again, 30 micrograms which is the full dose of Pfizer biotech. And you started off fairly at a fairly good level not as high as the Moderna you would have a very rigorous response. Just pretty much similar to the Moderna. And it’s sustained on day 29 as well. And you could see here if you go through the same things like we went through. If you had J&J  initially and then you had the j&j as a booster. You can see here that you started lower, you have a little bit of response roughly about four times on day 15. So this was less of a response compared to the Moderna boost and you can see that  actually starts to increase a little bit on day 29. But still not as high as if you had gotten the Moderna as a booster you can see you can compare the day 15 easier 3203 versus 326. So  if you had Moderna and you got the j&j  boost You do have a response, which is 3000 but it is not as high as if you had a  Moderna boost. It continues to increase however, by day 29. And then in terms of  Pfizer,  not as high as if your Moderna as booster for the for Pfizer, similar kinds of things that you could see you get a boost at day 15 actually goes a little bit higher and day 29 So there may be a slight delayed effect of J&J as it goes on, however, the amount is still not as high and vigorous as a third Pfizer dose would be and this is if you got Pfizer .  If you got j&j and Pfizer. You get a pretty good response as well. Not quite as high as if you had the Moderna as the booster. The data is incomplete. These are in process because the data has not been completely at this disciplinary study. And again, if you have Moderna and then you got Pfizer. Again, pretty good response.  it’s not quite as good as Maderna as a booster but statistically is in the same ballpark. Again, unknown about day 29 And then same thing if you’re the Pfizer and then you got a second Pfizer. It looks like a pretty good response as well. These neutralizing antibodies and is actually the numbers look more but this is a different scale looking at different types of antibodies that might be actually more meaningful. And you can see here the neutralizing antibodies for the missus the J and J to start with was at nine or 8.9 versus the Maderna 80.7 and the Pfizer at 24.8. That’s all at the baseline on day one. So that’s without the booster. So you can see that neutralizing antibodies are higher from the z and Pfizer after their two shot vaccine. Now, if you got the Moderna this is what the first group here is the j&j It goes way up as you can see about 76 times and is sustained. It’s sustained  on day 29 as well. And from Moderna you get a vigorous response as well. That is sustained. Same with Pfizer, and he sustained and all the rest of these numbers you can see here, very similar. We don’t have day 29 data for a lot of these neutralizing antibodies, so I’m not going to go through every single one, but you can understand the rationale that I’m showing you. So another way to look at this, which may be more helpful as graphically. If you look at the graph here,I could increase the size. You can see here, this group is j&j. This group is Moderna. And this group is Pfizer. So you can see here with the j&j in this first box, with the Modrona boost that you start lower, but you’re actually quite high by day 15 and sustained at 29. So graphically you can see that this is quite a vigorous response. If you had the Maderna you started off higher and you got this boost and that was sustained as well. It might be slightly higher into the antibodies and the j&j. But the protection you can see is quite boosted in the j&j. Much more similar than before the boost. And then if you had Pfizer biotech, you start off about the same level as the Maderna and you get a similar boost. So it looks like if you had the j&j which is the rationale for the CDC, suggesting everybody over age 18 Get a second. Get a booster. You can see that it brings you pretty much with parity with the other messenger RNA, presumably increasing protection. Now this doesn’t measure T cells and other components, so the immune system, but assuming that most of the protection is from antibodies initially this would bring you closer so in theory, at least less chance of having symptoms even with the j&j initially if you had the boost. This was looking at j&j as a booster. And you can see that you do get a boost with the Maderna and the Pfizer. Not quite as high as you do with the Maderna boost. But the j&j doesn’t quite bring you to parity with the others if you had a second j&j. And it’s not clear why they would be. It’s possible that since it’s an adenovirus vector, that your body’s already used to the initial ad no virus and takes it apart faster than you would get the full effect of production of the spike protein. The second time but again, that’s just speculation. This looks at the boost with the buy in tech. And you can see again, with all three, you get a pretty good boost that we don’t have the day 29 data but you do get a boost. And you get closer to parity with the Pfizer buy in tech. The other ones are for the neutralizing antibodies. And you could take a look at that as well. But since it’s an incomplete data set, without the de 29 We won’t go into as much detail and those so, So bottom line conclusion is it looks like you can get any of these as a booster, Pfizer, half dose Moderna and j&j. But if you had the Pfizer then you’d probably be better off with either repeating with a Pfizer or the half dose Maderna if you had the Moderna so the highest number generator would be the Maderna. And pretty much similar with the Pfizer, the j&j Boost did not boost as much, however, the day 29 data was still increasing. So it’s possible you might get better as time goes on. But the interesting thing about the j&j is that if you get a booster with the Maderna This brings you almost pretty much at parity with the others but not so much with the second j&j In intermediate with the Pfizer. So according to the preliminary data, if you had j&j, you would probably want to go with the half dose Moderna as your booster as of the data right now. So despite the boosters and antibodies, ultimately the best defense is still your immune system. So having a strong immune system through lifestyle, nutrition, supplements, and keeping overall health is key to optimizing your immune system. So for AFH programs on optimizing your immune health, and other AFH  anti-aging and regenerative medicine programs including our course on optimizing your immunity, obtain Probio 350Probio PlusProBio 100ProBio 30 SBPomBioX, and ProBio Phyto (Rainbow) or participate in other brain cognitive medicine programs, contact us at info@jeffreymarkmd.com, find us at www.allfunctionalhealth.com to schedule an appointment, or call (925) 736-9828.  

 

We’ve helped thousands of people on their health journey and look forward to helping you. Take care and stay healthy.

 

Jeffrey Mark, M.D.

 

 

 

Our office location in San Ramon is a short drive to the Silicon Valley including Palo Alto, Menlo Park, Atherton, Portola Valley, Los Altos, Los Altos Hills, San Jose, Cupertino, Mountain View, Burlingame, Hillsborough, San Mateo, San Francisco, Piedmont, Berkeley, Walnut Creek, Danville, Pleasanton, and surrounding areas. Telemedicine/Telehealth services are now available in the comfort of your home so no need to drive across the bay anymore to access your Quadruple Board Certified physician.   We are able to service all 50 states and send test kits and nutraceuticals directly to your home. Call us to find out more about our many services.  925-736-9828

 

Our office location in San Ramon is a short drive to the Silicon Valley including Palo Alto, Menlo Park, Atherton, Portola Valley, Los Altos, Los Altos Hills, San Jose, Cupertino, Mountain View, Burlingame, Hillsborough, San Mateo, San Francisco, Piedmont, Berkeley, Walnut Creek, Danville, Pleasanton, and surrounding areas. Telemedicine/Telehealth services are now available in the comfort of your home so no need to drive across the bay anymore to access your Quadruple Board Certified physician.   We are able to service all 50 states and send test kits and nutraceuticals directly to your home. Call us to find out more about our many services.  925-736-9828

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Author

Jeffrey Mark, M.D.
Helping clients with compassionate and comprehensive medical care for over 25 years with 4 board certifications in functional medicine, gastroenterology, internal medicine, and anti-aging/ regenerative medicine . IFMCP, ABIM Gastroenterology, NPAS Internal Medicine, ABAARM.

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